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Managing osteoporosis in patients on long-term bisphosphonate treatment: report of a task force of the American Society for Bone and Mineral Research.

Advancing age and the onset of menopause further increase the rate of bone resorption, magnifying the impact of the remodeling imbalance.

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When the treatment groups were compared by baseline categories of age, history of lobular carcinoma in situ (LCIS), history of atypical hyperplasia, Gail model-derived 5-year predicted risk of breast cancer and the number of relatives with a history of breast cancer, the pattern of no differential effect by treatment assignment was consistent, and none of the RRs in these subsets were statistically significant.

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Raloxifene has similar risk-reduction activity when compared with tamoxifen but has less toxicity, particularly on the uterus, making it a more attractive option than tamoxifen for use as a breast cancer risk-reduction agent in postmenopausal healthy women.

However, in those cases where the physical, mental, and emotional effects of perimenopause are strong enough that they significantly disrupt the life of the woman experiencing them, palliative medical therapy may sometimes be appropriate.

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Raloxifene (Evista) mimics estrogen's beneficial effects on bone density in postmenopausal women, without some of the risks associated with estrogen.

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Among UGTs, UGT1A1, UGT1A8, UGT1A9, and UGT1A10 showed the highest activity of raloxifene glucuronidation ().

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There was no clinically detectable delay to fracture healing via external callus formation following bisphosphonates treatment.

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Raloxifene is a less potent antiresorptive agent than bisphosphonates.

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The results from a noninferiority analysis are consistent with raloxifene HCl potentially losing up to 35% of the tamoxifen effect on reduction of invasive breast cancer.

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She told me she is not entirely convinced that estrogen lengthens lifespan but she uses HRT anyway because she just does not feel well enough without it.

Levothyroxine ( Synthroid) should be taken at least two hours before these minerals.

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The decoction of kidney- and spleen-invigoration and bone strengthening is safe, free of side effects, and is effective against the clinical symptoms of osteoporosis.

Taking medication to prevent or treat osteopenia and osteoporosis does not mean that intake of calcium and vitamin D is no longer needed.

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Allowing administration of concomitant medications (for example, benzodiazepines) that may interfere with cognitive function would also be a potential limitation.

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Within a given T-score range, the estimated time for the transition from osteopenia to osteoporosis was longer with younger age ( Table 3 Interval between Baseline Osteopenia and the Development of Osteoporosis in 10% of Study Participants, According to Age, BMI, and Estrogen-Use Status.

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Of the total number of patients in placebo-controlled clinical studies of raloxifene hydrochloride, 61% were 65 and over, while 15.

For both raloxifene and teriparatide, markers of bone resorption are relatively unchanged between 6 and 12 months of treatment.

The doctor then uses this comparison to determine the standard deviation (SD) from this norm.

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Ibandronate also has been added to the FDA-approved list for the prevention and treatment of postmenopausal osteoporosis.

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According to the prescribing information, the most commonly reported side effects associated with Evista treatment include hot flashes, leg cramps, peripheral edema (swelling in the legs, ankles, and feet), flu-like symptoms, arthralgia (joint pain) and sweating.

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Raloxifene restores both bone mineral density and TGF beta 3 messenger RNA expression in the femur to levels measured in intact rats.

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Daily supplement of vitamin D at 800 IU is associated with a lower incidence of falls in the aged patient.

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Bone turnover markers, such as serum alkaline phosphatase level, serum osteocalcin level and urinary calcium excretion, were found to be similarly decreased in both the raloxifene and the estrogen groups.

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Concomitant use of the prescriptions for bone strengthening and kidney nourishment, prescriptions for blood and qi replenishment and vitamin D supplement is associated with significant differences in BMD, estradiol level, testosterone level and tartrate-resistant acid phosphatase after treatment.

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