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If a cause is not identified, then anemia due to myelosuppressive chemotherapy is considered.
Anemia may be directly related to cancer type or to its treatment.
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Erythropoietin delays disease onset in an amyotrophic lateral sclerosis model.
ESAs are contraindicated in patients with hypersensitivity to non-human cell-derived products.
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The present invention is based on methods for the production of glycosylated polypeptides, including polypeptides with substantially reduced or no Neu5Gc content.
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Dr Simon D Roger, Department of Renal Medicine, Gosford Hospital, Gosford, NSW 2250, Australia.
Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities.
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Effects of anti-Neu5Gc antibodies on the kinetics of Cet and Pan in mice with a human-like Neu5Gc-deficiency.
Cardiovascular risk factors and prevention of cardiovascular disease in patients with chronic renal disease.
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Summary and Comment: CHOIR, CREATE, and Anemia Treatment in Patients with CKD.
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The invention particularly contemplates formulations and methods in which the concentration of therapeutic protein results in a viscosity of at least 6, 8, 10, 12, 14, 16, 18, 20, 25, 30 cP or higher and the inclusion of creatine, creatinine, carnitine, or a combination thereof results in the reduction of the viscosity by 5% or greater.
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