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Lower doses and shorter duration of T 3 application yielded different results: Sandrini et al found no significant effect on 5-HT 2 receptor density in the hippocampus and a decrease in cortical 5-HT 2 receptor density after application of T 3 in euthyroid rats (100 g kg - 1 for 3 -7 days).

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Untreated hypothyroidism can, over time, cause mental and behavioral impairment and, eventually, even dementia (memory loss).

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Neurodevelopmental outcomes in congenital hypothyroidism: comparison of initial T4 dose and time to reach target T4 and TSH.

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However, caution is necessary in interpreting results of thyroid function tests in neonates, because serum T 4 concentrations are transiently elevated and serum T 3 concentrations are transiently low, and the infant pituitary is relatively insensitive to the negative feedback effect of thyroid hormones.

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