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IV cidofovir has been used to treat a child with acyclovir and foscarnet resistant HSV ( 867).

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Humoral as well as cellular immunosuppression may be common in patients treated with these agents, especially in those who are heavily pretreated.

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In Study 901 tenofovir disoproxil fumarate 600 mg was administered to 8 patients orally for 28 days.

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The potential for protection with oral or topical antiretroviral agents, which we anticipated would have distinct safety, acceptability, and pharmacokinetic profiles, informed the design of the Vaginal and Oral Interventions to Control the Epidemic (VOICE) trial (MTN-003), which was initiated while the trials described above were under way.

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