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I was on one Clozapine for more than three years, for my schizophrenia case. This medication managed to produce effects that surpassed my best expectations and hopes. It provided me with complete control over my mood and emotions, my motivation increased many times, I hadn't had a single breakdown since the day I started on Clozapine. For me it is the best solution and I don't even think about changing medicine.

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Clozapine improves antiparkinsonian drug-induced psychosis.

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CLZ is also contraindicated in patients with myeloproliferative disorders and a history of toxic or idiosyncratic agranulocytosis or severe granulocytopenia.

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It should not be forgotten, however, that QTc prolongation is more common, and the risk of TdP is higher, when antipsychotic drugs and other psychotropic drugs are given in combination ().

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Do you actually believe that all of the most highly respected and educated psychiatrists that treat schizophrenia today are using drugs that "damage" the brain because they don't know any better or don't care!

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Hippisley-Cox: Antipsychotic drugs and risk of venous thromboembolism: nested case-control study.

Guideline-Concordant Antipsychotic Use and Mortality in Schizophrenia.

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Reduction of suicidality during clozapine treatment of neuroleptic-resistant schizophrenia: impact on risk-benefit assessment.

Compliance, as measured by pill counts, was 96 percent in the placebo group and 98 percent in the clozapine group.

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CLZ-induced urinary incontinence often occurs as nocturnal enuresis and generally develops within the first few days after starting therapy.

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Before entering the study, each patient was treated as deemed most appropriate by the enrolling investigator but without an antipsychotic drug.

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Conventional antipsychotic agents show therapeutic limitations because of their side-effects and inefficacy among some patients.

The outcome for coma and vegetative state depends on the cause, location, severity and extent of neurological damage.

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Acute dystonia typically develops shortly after taking an antipsychotic drug.

In a study of 77 cases of drug-associated TdP, two or more additional risk factors were present in 85%: heart disease (77%), age over 65 (54%), female sex (69%), and hypokalemia (30%) ().

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Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as clozapine have an increased chance of death during treatment.

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Preface: Failing in my efforts to get this article published for the general public, apparently only here can I talk about a “cool subculture of anti-authoritarians” and how the Harrow study shows medication resisters have greater recovery.

Generally, patients with clozapine-related myocarditis or cardiomyopathy should not be rechallenged with clozapine.

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The clinical benefits and cost savings associated with clozapine were less pronounced than in previous studies.

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This medication may pass into breast milk and have undesirable effects on a nursing infant.

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To prevent the enrollment of patients whose improvement was the result of an adjustment of their antiparkinsonian medication, all the patients had to have been taking a fixed dose of medication for at least seven days before enrollment.

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The dose of clozapine had no effect on the risk of agranulocytosis in the conditional logistic-regression analyses.

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Specifically, there are currently only 2 FDA approved pharmacotherapies to treat depression in patients with bipolar depression, including 1 medication (Quetiapine) and 1 medication combination (Olanzapine with Fluoxetine).

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However, Harrow makes clear, “At the 2-year assessment there were no significant differences in severity of psychosis between SZ on antipsychotic medications and SZ not on any medications.

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Patients were more satisfied with clozapine treatment than with typical neuroleptic treatment.

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Research Policies for Schizophrenia in the Global Health Context.

Estudios más recientes similares a este realizados por prominentes investigadores en el campo del trastorno bipolar muestran pruebas de una prevalencia mucho mayor de lo que se pensaba de afecciones bipolares en la población general.

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