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ACOG recommends that women with gestational diabetes who are on insulin or who have poor glucose control have the same antenatal monitoring as women with pregestational diabetes.

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You should not use this medication if you are allergic to glyburide or metformin, if you have kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

This helps combat insulin resistance and is what makes exercise helpful to people with diabetes.

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Miconazole (Oral): May enhance the hypoglycemic effect of Sulfonylureas.

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Copyright, The American Society of Health-System Pharmacists, Inc.

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In women with diabetes, maternal hyperglycemia can be associated with congenital malformations as well as adverse effects in the fetus, neonate, and the mother (ACOG 2005; ADA 2015; Kitzmiller 2008; Metzger 2007).

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In patients with advanced age, glyburide and metformin hydrochloride should be carefully titrated to establish the minimum dose for adequate glycemic effect, because aging is associated with reduced renal function.

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Reproduction studies were performed in rats and rabbits at doses up to 500 times the MRHD dose of 20 mg of the glyburide component of glyburide and metformin hydrochloride based on body surface area comparisons and revealed no evidence of impaired fertility or harm to the fetus due to glyburide.

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