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Of the imidazoles, ketoconazole is fungistatic, but clotrimazole is fungicidal; miconazole is fungistatic at lower dosages and fungicidal at higher dosages.
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The plot shows 12 chemical screens that interacted with 647 different genes.
Vaginal candidiasis: The recommended dosage of fluconazole for vaginal candidiasis is 150 mg as a single oral dose.
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The AUC and C max of midazolam were significantly higher after oral than IV administration of Fluconazole.
Subtle chemical differences exist; however, the galactomannan of Aspergillus has striking structural similarity to that of Penicillium.
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Fungal surveillance cultures of the nasopharynx (tracheal secretions if the infant was intubated and nasopharyngeal sample if the infant was not intubated), skin (groin), and stool or rectum were obtained, by two clinical nurses associated with the study, at base line and then weekly during the six-week study period on the day of the week of the patient's enrollment.
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Contribution of a Simple Bioassay in Effective Therapeutic Drug Monitoring of Posaconazole and Voriconazole.
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Alfentanil: A study observed a reduction in clearance and distribution volume as well as prolongation of T ½ of alfentanil following concomitant treatment with fluconazole.
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In a mouse model of invasive aspergillosis, cyclosporine, tacrolimus, and rapamycin had no impact on survival ().
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Aspergillus fumigatus evades immune recognition during germination through loss of Toll-like receptor-4-mediated signal transduction.
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PD) data, susceptibility in vitro and clinical response EUCAST-AFST (European Committee on Antimicrobial susceptibility Testing-subcommittee on Antifungal Susceptibility Testing) has determined breakpoints for fluconazole for Candida species (EUCAST Fluconazole rational document (2007)-version 2).
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There were also no significant differences between the placebo and fluconazole groups in the incidence of isolated intestinal perforation (5 infants and 2 infants, respectively), ligation of patent ductus arteriosus (5 infants and 2 infants, respectively), threshold retinopathy of prematurity (11 infants and 15 infants, respectively), or abnormal findings on cranial ultrasonography (9 infants and 8 infants, respectively).
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In another study, a higher grade of GVHD and a longer duration of corticosteroid therapy portended a significant risk for invasive aspergillosis in nonmyeloablative transplant recipients ().
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Updated guidelines for managing fungal diseases in hematology patients.
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Almost two thirds (61%) of patients with invasive aspergillosis have an underlying hematologic disease, or have undergone bone marrow transplantation (BMT).
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Abbott M, Hughes DL, Patel R, Kinghorn GR "Angio-oedema after fluconazole.
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