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In the case of death by suicide, a small study reported that it did not occur, therefore the treatment effect was not estimable.

No reliable studies support the use of other minor tranquilizers such as oxazepam (Serax), chlordiazepoxide (Librium) or clorazepate (Tranxene), although these drugs may make the patient feel somewhat calmer.

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It may be necessary to increase the clozapine dose if used concomitantly with inducers of these enzymes.

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One study () that compared clozapine with risperidone used the criterion of at least 40% improvement on the BPRS psychotics cluster (cluster: hallucinations, delusions, suspiciousness and conceptual disorganization).

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The cause has not been established but life case histories suggest that some schizophrenics have adopted an alternative reality as an escape from an intolerable life situation.

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