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Initial treatment of high-normal blood pressure (systolic or diastolic blood pressure consistently above the 90th percentile for age, sex, and height) includes dietary intervention and exercise, aimed at weight control and increased physical activity, if appropriate.

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In the RENAAL study, 1513 patients with type 2 diabetes and nephropathy were randomly assigned to losartan or placebo, both in addition to conventional anti-hypertensive therapy (excluding ACEI).

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ALLHAT patients were receiving an antihypertensive drug, a diuretic in most cases, at the time of randomization, when they abruptly abandoned the previous agents and were fully switched to trials drugs.

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The triggering effect of exercise and tachycardia, and therefore the protective effect of beta-blockers, varies depending on the type of LQTS.

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