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It is gradual for some and quite sudden for others, but nearly all patients with a lifelimiting illness stop eating and drinking at some point.

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Only 1 patient developed diabetes in the enalapril group compared with 12 patients in the placebo group, which represents an absolute risk reduction of 45% ().

It is widely believed that hearing is the last sense to go so it is recommended that loved ones sit with and loved one during this time.

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This clinical trial is one of three clinical trials of the European-Commission (FP7)-funded "LENA" (Labeling of Enalapril from Neonates up to Adolescents) project: 50 children with heart failure due to dilated cardiomyopathy (LENA-Work Package (WP) 08 Trial) and 50 children with heart failure due to congenital heart disease (LENA-WP09 Trial) get treated with an optimal dose of enalapril ODMTs for up to 8 weeks after thorough, individualised titration and get invited to join the 10 months Safety Follow-up Study (LENA-WP10 Trial).

There have been many advances in the diagnosis, treatment and prevention of these syndromes in the last several years.

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